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US 2026/0118260 A1Published application
Optical methods and systems for glucose measurement
OwnerAnoushka S. NAIR, Dylan N. STRIEKinventors
Life of this patent
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Abstract
The present disclosure teaches methods for optical estimation of blood glucose. In some embodiments, the disclosed methods involve estimating glucose levels based on absorbance detection of at least one electrolyte. Also provided are apparatuses for optical estimation of blood glucose, including instructions for use. In some embodiments, the apparatuses include light emitting units configured to emit light at specific wavelengths.
Claims20
An apparatus for quantifying blood glucose, the apparatus comprising:
- a) a grip for releasably gripping a blood sample, the grip comprising first and second housings interconnected by a pivot configured to position the first and second housings relative to one another to releasably grip the blood sample inserted between the first and second housings, the first and second housings being in electrical communication with each other;
- b) a light emitting unit comprised at least partially within the first housing;
- the light emitting unit positioned so as to direct light towards the second housing, through the blood sample gripped between the first and second housings, the light emitting unit comprising at least two of:
- i) a light source capable of emitting light at 740-780 nm;
- ii) a light source capable of emitting light at 580-620 nm;
- and
- iii) a light source capable of emitting light at 450-490 nm;
- c) a light sensing unit comprised at least partially within the second housing;
- the light sensing unit comprising a photodetector capable of measuring light transmittance from the light emitting unit, through the gripped blood sample;
- and
- d) a processor configured to receive data from the photodetector indicative of a concentration of one or more electrolytes in the blood sample and determine a glucose concentration of the blood sample based on the concentration of the one or more electrolytes,
- wherein the one or more electrolytes comprise sodium, potassium, phosphate, or a combination thereof.
9 more elements
A method for quantifying blood glucose level, the method comprising the steps of:
- a) measuring, via a photodetector, absorbance of blood from a light within at least two of the following wavelength ranges:
- i) 740-780 nm;
- ii) 580-620 nm;
- iii) 450-490 nm;
- and
- b) determining glucose content estimates from the absorbance measurements from (a) by:
- i) dividing the absorbance measured in (a)(i) by (about 1.247×Li);
- ii) dividing the absorbance measured in (a)(ii) by (about 3.727×Lii);
- iii) dividing the absorbance measured in (a)(iii) by (about 3.533×Liii);
- and
- iv) separately applying a regression model to the values of step (b)(i)-(iii), thereby producing a plurality of glucose content estimates;
- and
- c) reconciling the glucose content estimates from step (b), thereby quantifying blood glucose level of the blood,
- wherein L(i-iii) is distance each light travels though the blood in each of elements (a)(i)-(iii), respectively.
11 more elements
Dependencies are inferred from the claim text.