Preparation Method and Application of Imidazole-Functionalized Metal-Organic Framework Material Im RE-MOF With Lipase-Mimetic Catalytic Activity

Abstract

Disclosed is a preparation method and application of an imidazole-functionalized metal-organic framework material, Im@RE-MOF, with a lipase-mimetic catalytic activity. The method introduces an imidazole group into a benzene tricarboxylic acid framework through acyl chlorination and Friedel-Crafts acylation reactions to prepare an imidazole-functionalized organic ligand, and the functionalized ligand is self-assembled with a rare earth or transition metal ion (RE=Zr, Sc, or Cd) by a solvothermal method to obtain a target product Im@RE-MOF. The enzyme-mimetic material effectively mimics the catalytic center of natural lipase due to the regular pore structure of the MOF and the catalytic activity of the imidazole group. The material has a stable structure, high catalytic activity, and easy separation and recovery, can catalyze hydrolysis and synthesis reactions of carboxylic esters under mild conditions; overcomes limitations of poor stability and difficulty in recovery of natural lipase; and has broad application prospects in the fields of green chemical industry and organic synthesis.

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