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AssigneePikralida SpóLka Z Ograniczona Odpowiedzialnoscia
InventorsMarek MASNYK, Katarzyna SIDORYK, Lukasz MUCHA, Marta MAGDYCZ, Magdalena TYSZKIEWICZ, Stanislaw PIKUL
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The invention relates to a crystalline polymorphic form I, II and III of marimastat, a mixture of the crystalline polymorphic form I and III of marimastat, an amorphous form of marimastat, and processes for their preparation. The invention further relates to a pharmaceutical composition comprising the crystalline polymorphic form I, II or III of marimastat, the mixture of the crystalline polymorphic form I and III of marimastat, the amorphous form of marimastat or a mixture thereof. The invention also relates to the pharmaceutical composition for use as a medicament, and for use in the prevention and treatment of diseases associated with hyperactivity of extracellular matrix metalloproteinases. The invention further relates to the crystalline polymorphic form I, II or III of marimastat, the mixture of the crystalline polymorphic form I and III of marimastat, the amorphous form of marimastat or a mixture thereof for use as a medicament, and for use in the prevention and treatment of diseases associated with hyperactivity of extracellular matrix metalloproteinases.
A crystalline polymorphic form of marimastat, which is the crystalline polymorphic form I, characterized by a powder X-ray diffraction pattern obtained by irradiation with Cu Kα radiation, which includes main peaks at 2-Theta° 6.11, 11.10, 12.19, 18.15, 19.57, 20.54, 20.74, 23.35, 24.50 and 26.20±0.2.
A crystalline polymorphic form of marimastat, which is the crystalline polymorphic form II, characterized by a powder X-ray diffraction pattern obtained by irradiation with Cu Kα radiation, which includes main peaks at 2-Theta° 6.18, 12.26, 14.95, 19.74, 21.53, 24.55, 24.55, 27.73, 30.80 and 37.12±0.2.
A crystalline polymorphic form of marimastat, which is the crystalline polymorphic form III, characterized by a powder X-ray diffraction pattern obtained by irradiation with Cu Kα radiation, which includes main peaks at 2-Theta° 6.32, 11.05, 12.60, 17.30, 18.36, 20.43, 20.93, 24.05, 26.83 and 40.30±0.2.
A mixture of the crystalline polymorphic form I of marimastat and the crystalline polymorphic form III of marimastat, characterized by a powder X-ray diffraction pattern obtained by irradiation with Cu Kα radiation, which includes main peaks at 2-Theta° 6.14, 6.30, 11.09, 12.22, 12.60, 18.43, 19.62, 20.51, 20.78 and 20.98±0.2.
An amorphous form of marimastat.
Dependencies are inferred from the claim text.