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AssigneeBoston Scientific Scimed, Inc.
InventorYen-Hao Hsu
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In some aspects, the present disclosure provides radiopaque, reactive polymers that comprise (i) one or more hydrophilic polymer regions, the one or more hydrophilic polymer regions having first and second ends and comprising at least one hydrophilic polymer segment, (ii) a plurality of iodinated amino-alcohol compound residues, wherein at least one of the plurality of iodinated amino-alcohol compound residues is linked to each of the hydrophilic polymer regions, and (iii) a plurality of reactive moieties, wherein at least one of the plurality of reactive moieties is linked to each of the plurality of iodinated amino-alcohol compound residues and wherein the reactive moieties each comprise an electrophilic group. In other aspects, the present disclosure pertains to methods of forming such radiopaque, reactive polymers, to systems for forming hydrogel compositions based on such radiopaque, reactive polymers, and to methods of treatment using such radiopaque, reactive polymers.
A radiopaque, reactive polymer comprising (a) one or more hydrophilic polymer regions, the one or more hydrophilic polymer regions having first and second ends and comprising at least one hydrophilic polymer segment, (b) a plurality of iodinated amino-alcohol compound residues, wherein at least one of the plurality of iodinated amino-alcohol compound residues is linked to each of the hydrophilic polymer regions, and (c) a plurality of reactive moieties, wherein at least one of the plurality of reactive moieties is linked to each of the plurality of iodinated amino-alcohol compound residues and wherein the reactive moieties each comprise an electrophilic group.
A system for forming a hydrogel composition that comprises (a) a compound having a plurality of nucleophilic moieties and (b) a radiopaque, reactive polymer comprising (i) one or more hydrophilic polymer regions, the one or more hydrophilic polymer regions having first and second ends and comprising at least one hydrophilic polymer segment, (ii) a plurality of iodinated amino-alcohol compound residues, wherein at least one of the plurality of iodinated amino-alcohol compound residues is linked to each of the hydrophilic polymer regions, and (iii) a plurality of reactive moieties, wherein at least one of the plurality of reactive moieties is linked to each of the plurality of iodinated amino-alcohol compound residues and wherein the reactive moieties each comprise an electrophilic group.
A method of treatment comprising administering to a subject a mixture that comprises (a) a compound having a plurality of nucleophilic moieties;
Dependencies are inferred from the claim text.