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US 2026/0115310 A1Published application
Compositions and methods for making antibody conjugates
AssigneeThe Trustees of the University of Pennsylvania
InventorsAndrew TSOURKAS, James Z. HUI
Life of this patent
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Abstract
The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions for imaging, diagnosing or treating a disease.
Claims33
-167. (canceled)
An adapter comprising a first antibody binding domain (AbBD) fused to a second antibody binding domains (AbBD),
- wherein the first AbBD has one or more amino acids or amino acid modifications that are adapted to specifically bind and crosslink to a first immunoglobulin or a fragment thereof,
- wherein the second AbBD has one or more amino acids or amino acid modifications that are adapted to specifically bind and crosslink to a second immunoglobulin or a fragment thereof, and
- wherein the first and second AbBDs are each selected from Protein A, Protein G, Protein L, CD4 and subdomains thereof.
(canceled)
-322. (canceled)
Dependencies are inferred from the claim text.