Tumor-specific cleavable linkers
AssigneeXilio Development, Inc.
InventorsRaphael Rozenfeld, Ugur ESKIOCAK, Huawei QIU, Parker JOHNSON, Kurt Allen JENKINS, Magali PEDERZOLI-RIBEIL, Dheeraj Singh TOMAR, Rebekah Kay O'DONNELL
Life of this patent
Estimating the term…
Abstract
The present disclosure provides tumor-specific cleavable linkers and their use in drugs and prodrugs for delivering therapeutics to a tumor cell environment. The present disclosure also provides cleavage products of said drugs and prodrugs, and methods related to the use of the same.
Claims33
A polypeptide drug construct comprising (i) a therapeutic moiety;
- (ii) a carrier moiety and (iii) a proteolytically cleavable peptide linker comprising a proteolytically cleavable peptide (CP).
3-5. (canceled)
7-15. (canceled)
17-19. (canceled)
21-23. (canceled)
25-26. (canceled)
28-31. (canceled)
A masked cytokine comprising:
- a) a first polypeptide chain comprising a masking moiety linked to a first half-life extension moiety via a first linker;
- and
- b) a second polypeptide chain comprising a cytokine moiety thereof linked to a second half-life extension moiety via a second linker,
- wherein the first half-life extension moiety is associated with the second half-life extension moiety, and
- wherein at the first linker or the second linker is a proteolytically cleavable peptide linker comprising a proteolytically cleavable peptide (CP).
33-35. (canceled)
A masked cytokine comprising a polypeptide chain comprising formula:
- where HL is the half-life extension domain, L1 is the first linker, MM is the masking moiety, L2 is the second linker, and C is the cytokine moiety,
- wherein at least the first linker comprises a proteolytically cleavable peptide linker comprising a proteolytically cleavable peptide (CP).
A masked cytokine comprising a polypeptide chain comprising formula:
- where HL is the half-life extension domain, L1 is the first linker, MM is the masking moiety, L2 is the second linker, and C is the cytokine moiety thereof,
- wherein at least the first linker comprises a proteolytically cleavable peptide linker comprising a proteolytically cleavable peptide (CP).
39-51. (canceled)
-56. (canceled)
-154. (canceled)
157-161. (canceled)
-182. (canceled)
184-190. (canceled)
-203. (canceled)
Dependencies are inferred from the claim text.