Detection of cancer biomarkers using nanoparticles
AssigneeThe University of Manchester
InventorsKostas KOSTARELOS, Marilena HADJIDEMETRIOU
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Abstract
The present invention relates to methods for identifying and detecting potential disease specific biomarkers from biofluids. In particular, the methods involve in vivo administration of nanoparticles to a subject in a diseased state or incubating nanoparticles in a biofluid sample taken from a subject in a diseased state and analysis of the biomolecule corona formed on said nanoparticles. In addition, the present invention also relates to methods that provide a means to distinguish between a healthy and diseased state in a subject, such as for example the presence of a tumor in a human subject.
Claims1
A method of identifying a biomarker from a biofluid, wherein the method comprises:
- a. administering a plurality of nanoparticles to a subject in a diseased state to allow a biomolecule corona to form on the surface of said nanoparticles or incubating a plurality of nanoparticles in a biofluid sample taken from a subject in a diseased state to allow a biomolecule corona to form on the surface of said nanoparticles;
- b. isolating the nanoparticles and surface-bound biomolecule corona;
- and
- c. analyzing the biomolecule corona to identify the said biomarker.
Dependencies are inferred from the claim text.