Cellular compositions and methods of treatment i
AssigneeMesoblast International Sarl
InventorsPeter BRINK, Ira COHEN, Richard LIN, Sergey DORONIN, Irina POTAPOVA, Virginijus VALIUNAS, Dan DEVINE, Anthony SANDRASAGRA, Nick LOIZOS, Silviu ITESCU
Life of this patent
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Abstract
The present disclosure relates to cellular compositions that are modified to introduce a nucleic acid or vector expressing the same. Such compositions may be used to deliver nucleic acid to a target cell and treat disease such as cancer.
Claims20
(canceled)
A method of treating cancer in a subject, the method comprising administering to the subject a composition comprising mesenchymal precursor cells (MPSCs), mesenchymal stem cells (MSCs) or exosomes, wherein the MPCs, MSCs or exosomes comprise an inhibitory oligonucleotide, wherein the inhibitory oligonucleotide is selected from the group consisting of:
- antisense, siRNA, shRNA, and miRNA.
(canceled)
5-7. (canceled)
10-15. (canceled)
The method of claim 14, wherein the MPCs or MSCs have been culture expanded from a population of STRO-1+ cells.
17-23. (canceled)
25-29. (canceled)
31-42. (canceled)
Dependencies are inferred from the claim text.