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US 2026/0109745 A1Published application
Colon and Pancreas Cancer Peptidomimetics
AssigneePrecision Biologics, Inc.
InventorXue-Ping WANG
Life of this patent
Estimating the term…
Abstract
The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods.
Claims27
An isolated polypeptide selected from the following
- (i) a polypeptide which is at least about 80% identical to the amino acid sequence of SX1PX2DX3FRYX4NX5 (SEQ ID NO:
- 1), wherein X1 is for L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- SX1PX2DX3FRYX4NX5K (SEQ ID NO:
- 2), wherein X1 is for L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- SLEPEX1DWX2FRYX3NY (SEQ ID NO:
- 3), wherein X1 is E or D;
- X2 is W or Y;
- and X3 is T or I;
- FPEDYFRYTNQK (SEQ ID NO:
- 4);
- SLPDDWFRYINY (SEQ ID NO:
- 5);
- (ii) a polypeptide which is at least about 90% identical to the amino acid sequence of SX1PX2DX3FRYX4NX5 (SEQ ID NO:
- 1), wherein X1 is for L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- SX1PX2DX3FRYX4NX5K (SEQ ID NO:
- 2), wherein X1 is for L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- (iii) a polypeptide comprising the amino acid sequence of LEPEX1DWX2FRYX3NY (SEO ID NO:
- 3), wherein X1 is E or D;
- X2 is W or Y;
- and X3 is T or I;
- FPEDYFRYTNQK (SEO ID NO:
- 4);
- SLPDDWFRYINY (SEO ID NO:
- 5);
- (iv) a polypeptide which comprises the amino acid sequence of SX1PX2DX3FRYX4NX5 (SEO ID NO:
- 1), wherein X1 is for L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- SX1 PX2DX3FRYX4NX5K (SEO ID NO:
- 2), wherein X1 is for L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- SLEPEX1DWX2FRYX3NY (SEO ID NO:
- 3), wherein X1 is E or D;
- X2 is W or Y;
- and X3 is T or I;
- FPEDYFRYTNQK (SEO ID NO:
- 4);
- SLPDDWFRYINY (SEO ID NO:
- 5);
- or
- (v) a polypeptide comprising any one of the amino acid sequences of SEO ID NOs:
- 6-24;
- or
- (vii) a fusion protein or protein conjugate comprising the polypeptide of any one of (i) to (v), which optionally is directly or indirectly covalently attached to a detectable label, optionally a polyHis tag, FLAG tag, MBP, GST protein, GFP, a chemiluminescent label, a paramagnetic label, an MRI contrast agent, a fluorescent label, a bioluminescent label, or a radioactive label;
- a cytotoxic agent, a therapeutic agent, a carbohydrate, an immunoglobulin or immunoglobulin fragment, or an immunomodulatory agent.
57 more elements
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Dependencies are inferred from the claim text.