Low particulate lubricious coating with vinyl pyrrolidone and acidic polymer-containing layers

A method making a coating on a medical device comprising:

• applying a first coating solution directly or indirectly on a medical device surface, the first coating solution comprising a vinyl pyrrolidone polymer and photoreactive groups, wherein the photoreactive groups are pendent from the vinyl pyrrolidone polymer or present on a first cross-linking agent comprising at least two photoreactive groups;
• and a first solvent, and drying the first coating solution;
• exposing the first coating solution to actinic radiation to form a first layer;
• applying a second coating solution onto the first layer, the second coating solution comprising an acrylic acid polymer, and a second solvent, and optionally a second cross-linking agent comprising at least two photoreactive groups, and drying the second coating solution;
• and
• exposing the second coating solution to actinic radiation to form a second layer.