THERAPEUTIC COMPOUND AND METHOD OF PREPARING A THERAPEUTIC VACCINE FOR THE TREATMENT OF ALLERGIC AND AUTOIMMUNE DISEAES USING IMMUNIZATION WITH ENGINEERED BACTERIAL DNA OR CpG MOTIFS DERIVIDE FROM COMMENSAL BACTERIA SUCH AS Bifidobacterium longun subsp. infantis.
OwnerJoseph A. Bellanti, Dongmei LIinventors
Life of this patent
Estimating the term…
Abstract
We disclose a biochemical compound comprising CpG moieties derived from human commensal bacteria that exhibit the ability to suppress immune system responses in patients that suffer from autoimmune and allergic diseases arising from overactive immune systems. We outline several methods for use of the compound in the treatment of individuals suffering from various types of auto-immune and related diseases.
Claims11
A vaccine composition comprising a motif (M) present in a human commensal bacterium, the motif possesses the capacity for Treg induction, wherein the motif (M) may undergo a bio-engineered process or a chemical process in order to achieve said capacity.
The vaccine composition of clam 7, wherein the association of a specific antigen with the CpG moiety prevents the general suppression of a cytokine response in cancer patients, and substitutes a Treg response specifically targeted against a known specific antigen.
Dependencies are inferred from the claim text.