Cholinergic gene therapy to preserve hearing

Abstract

Provided herein are vectors including a polynucleotide encoding an α9L9′T protein, pharmaceutical compositions including the vector including a polynucleotide encoding an α9L9′T protein, and methods of use thereof. The methods of use include methods of preventing hearing loss, methods of protecting against or treating acoustic trauma in a subject, methods of increasing sound evoked feedback inhibition in a subject, and methods of preventing noise-induced and/or age-related hearing loss in a subject. The methods include the intracochlear or other administration of the vectors including a polynucleotide encoding an α9L9′T protein or of the pharmaceutical compositions comprising the same.

Dependencies are inferred from the claim text.