Method and system for a normothermic machine perfusion of an ex vivo liver
AssigneeMedizinische Universität Innsbruck
InventorsStefan SCHNEEBERGER, Thomas RESCH
Life of this patent
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Abstract
A method and a system for a normothermic machine perfusion of an ex vivo liver is provided. The method comprises the following steps: (a) generating a flow of a perfusate through an ex vivo liver, (b) stimulating a bile secretion of the ex vivo liver, and (c) determining a volume of bile secreted by the ex vivo liver, and subsequently adding an oxygen carrier, e.g., whole blood to the perfusate, wherein the added oxygen carrier has a volume that equals at least 20% of the determined volume of secreted bile.
Claims19
A method for a normothermic machine perfusion of an ex vivo liver, comprising the following steps:
- (a) generating a flow of a perfusate through an ex vivo liver,
- (b) stimulating a bile secretion of the ex vivo liver,
- (c) determining a volume of bile secreted by the ex vivo liver, and subsequently adding an oxygen carrier, for example an oxygen carrier comprising or consisting of whole blood and/or red blood cells to the perfusate, wherein the added oxygen carrier has a volume that equals at least 20% of the determined volume of secreted bile.
A method for a normothermic machine perfusion of an ex vivo liver, comprising the following steps:
- (a) generating a flow of a perfusate through the ex vivo liver,
- (b) stimulating a bile secretion of the ex vivo liver,
- (c′) adding an oxygen carrier, for example an oxygen carrier comprising or consisting of whole blood and/or red blood cells to the perfusate such that a volume of the perfusate is held within a predetermined volume range.
A system for a normothermic machine perfusion of an ex vivo liver, particularly system for carrying out a method of any of the preceding claims, comprising
- a perfusate container for receiving a perfusate,
- an ex vivo liver container for holding the ex vivo liver,
- a pump for generating a flow of the perfusate through the ex vivo liver,
- means for determining a volume of bile secreted by the ex vivo liver,
- and/or means for determining a volume of perfusate, and/or
- means for determining a bile production rate.
Dependencies are inferred from the claim text.