Method, electronic device and storage medium

An electronic device comprising:

• at least one processor;
• and
• at least one memory storing instructions that, when executed by the at least one processor, cause the electronic device at least to:
• determine, based on a protein sequence and a first conformation, a plurality of first residue features for a plurality of residues in the first conformation and a plurality of second residue features for a plurality of residues in a second conformation, the protein sequence comprising a plurality of residues;
• update, based on temporal information and spatial information of the plurality of first residue features, the plurality of second residue features;
• and
• generate, based on the updated plurality of second residue features, the second conformation.

A non-transitory computer-readable storage medium comprising program instructions for causing an apparatus to:

• determine, based on a protein sequence and a first conformation, a plurality of first residue features for a plurality of residues in the first conformation and a plurality of second residue features for a plurality of residues in a second conformation, the protein sequence comprising a plurality of residues;
• update, based on temporal information and spatial information of the plurality of first residue features, the plurality of second residue features;
• and
• generate, based on the updated plurality of second residue features, the second conformation.