Drug discovery support apparatus, method for operating drug discovery support apparatus, and program for operating drug discovery support apparatus

A method for operating a drug discovery support apparatus, the method comprising:

• acquiring a first prediction value of a degree of inhibition indicating a degree to which a flow of ions in a plurality of ion channels present in an iPS myocardial cell, which is a myocardial cell derived from a human iPS cell, is inhibited by a candidate substance for a drug for each of the ion channels and for each added amount of the candidate substance, the first prediction value being output from a prediction model based on a first fluctuation waveform that is a fluctuation waveform of an extracellular potential of the iPS myocardial cell and is measured in a case where the candidate substance is added to the iPS myocardial cell while the added amount is changed;
• deriving an index value indicating a dose-response relationship of the candidate substance for each of the ion channels, based on the first prediction value for each added amount;
• and
• presenting, to a user, estimated reference information that corresponds to the index value and is referred to in order to estimate a mechanism of action of the candidate substance.

A non-transitory computer-readable storage medium storing a program for operating a drug discovery support apparatus, the program causing a computer to execute a process comprising:

• acquiring a first prediction value of a degree of inhibition indicating a degree to which a flow of ions in a plurality of ion channels present in an iPS myocardial cell, which is a myocardial cell derived from a human iPS cell, is inhibited by a candidate substance for a drug for each of the ion channels and for each added amount of the candidate substance, the first prediction value being output from a prediction model based on a first fluctuation waveform that is a fluctuation waveform of an extracellular potential of the iPS myocardial cell and is measured in a case where the candidate substance is added to the iPS myocardial cell while the added amount is changed;
• deriving an index value indicating a dose-response relationship of the candidate substance for each of the ion channels, based on the first prediction value for each added amount;
• and
• presenting, to a user, estimated reference information that corresponds to the index value and is referred to in order to estimate a mechanism of action of the candidate substance.