Fusions with cd8 antigen binding molecules for treating chronic viral infection

Abstract

Provided herein are methods of treating chronic viral infection (e.g., hepatitis B virus (HBV) and/or human immunodeficiency virus (HIV) infection) comprising administering to an individual in need thereof an effective amount of a fusion protein that comprises: (a) a first moiety comprising an antibody or antigen-binding fragment thereof that specifically binds human CD8b and/or human CD8ab with at least 10-fold higher affinity than its binding to human CD8a and/or human CD8aa; and (b) a second moiety comprising a cytokine, chemokine, or growth factor.

Dependencies are inferred from the claim text.