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AssigneeIndustry-Academic Cooperation Foundation, Yonsei University
InventorsHogeun YOON, Soo-Yeon PARK
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The present invention relates to a method for prevention or treatment of fibrotic disease, wherein an antibody binding specifically to Asporin protein involved in fibrosis is used for predicting the onset of fibrotic disease or for inhibiting the activity of the corresponding protein. The present invention provides an effective antibody that can be used for the diagnosis, prevention, and treatment of idiopathic pulmonary fibrosis, a condition for which efficient treatment methods have been absent because a clear pathogenic mechanism is not known therefor. In addition, the present invention can be advantageously used to effectively block fibrosis in various tissues by ultimately providing a fundamental inhibitory method for pathological fibrosis mechanisms.
An antibody to Asporin protein, or an antigen-binding fragment thereof, comprising a heavy chain variable region having a heavy chain complementarity determining region (CDR) amino acid sequence of HCDR1 having the sequence of SEQ ID NO:
(canceled)
An antibody to Asporin protein, or an antigen-binding fragment thereof, comprising a light chain variable region having the light chain complementarity determining region (CDR) amino acid sequence of LCDR1 having the sequence of SEQ ID NO:
Dependencies are inferred from the claim text.