Human aminosterol ent-03 compounds, related compositions comprising the same, and methods of using the same

A method of treating a subject in need having a condition susceptible to treatment with an aminosterol, comprising administering a therapeutically effective amount of an aminosterol compound, or a composition comprising the aminosterol compound, wherein the compound is selected from the group consisting of:

• (a) an aminosterol compound having the formula:
• wherein:
• R1 is H or D;
• and
• R2 is H or D
• provided that all of R1 are H, all of R2 are H, or all of R1 and R2 are H, or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof,
• (b) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof,
• (c) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• (d) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof:
• (e) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• (f) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• (g) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof:
• (h) an aminosterol compound having the formula:
• wherein:
• R1 is H, an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, and optionally substituted C1-C6 alkenyl;
• and
• R2 is H or —C(O)R3, wherein R3 is an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, or optionally substituted C1-C6 alkenyl;
• provided that at least one of R1 and R2 is not H,
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• (i) an aminosterol compound having the formula:
• wherein:
• R1 is H, an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, and optionally substituted C1-C6 alkenyl;
• and
• R2 is H or —C(O)R3, wherein R3 is an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, or optionally substituted C1-C6 alkenyl;
• provided that at least one of R1 and R2 is not H, or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• (i) an aminosterol compound having the formula:
• wherein:
• R1 is H, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, or optionally substituted C1-C6 alkenyl;
• and
• R2 is H or —C(O)R3, wherein R3 is an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkynyl, optionally substituted heterocyclyl, optionally substituted C3-C8 cycloalkyl, or optionally substituted C1-C6 alkenyl;
• provided that at least one of R1 and R2 is not H,
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• (k) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• (l) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• or
• (m) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• or
• (n) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof;
• or
• (o) an aminosterol compound having the formula:
• or a pharmaceutically acceptable salt, solvate, prodrug, or derivative thereof.