US 2026/0098034 A1 · 2H-BENZOTRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Abstract

The invention discloses a benzisothiazole compound as well as a pharmaceutical composition and application thereof, belongs to the technical field of medicines, and particularly relates to a 2H-benzotriazole substituted benzisothiazole compound with a novel structure as shown in a formula (I), a pharmaceutical composition containing the compound and application of the compound in preparation of medicines for treating and/or preventing premature ejaculation. Through in-vivo activity test research, the compound has obviously higher anti-premature ejaculation activity than the on-sale drug dapoxetine.

Claims10

Dependent claims

A 2H-benzotriazole derivative or a pharmaceutically acceptable salt thereof, characterized in that the structure of the derivative is as shown by formula (I):

wherein
X represents:
a C3-C4-alkyl or a C3-C4-alkoxy;
Y represents:
CH or N;
Z represents:
O or S;
R represents:
optional substitution of hydrogen atom(s) by 1-3 halogen atoms selected from the group consisting of fluorine, chlorine, bromine.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

19/112,922Filed 23 Aug 2023

Priority

CN 202211135547.319 Sep 2022

Published

9 Apr 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 413/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 413/14
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms:…
A61K 31/454
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/496
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: non-condensed piperazines…

2h-benzotriazole derivative, preparation method therefor, and pharmaceutical composition containing same

Life of this patent

2h-benzotriazole derivative, preparation method therefor, and pharmaceutical composition containing same

Life of this patent

Abstract

Claims10