Synthesis of nsaid conjugates as anti-inflammatory agents using the molecular hybridization

A compound having the structure of:

• wherein:
• (i) R1 is a halide, an unsubstituted alkyl, a substituted alkyl, an alkoxy, a nitro, a carbonyl, a hydroxyl, an amino, an amido, a cyano, a thio, an unsubstituted alkenyl, a substituted alkenyl, an unsubstituted alkynyl, a substituted alkynyl, an unsubstituted alkylaryl, a substituted alkylaryl, an unsubstituted aryl, or a substituted aryl;
• (ii) n is an integer from 0 to 5, from 0 to 4, from 0 to 3, or 1 or 2, such as 1;
• (iii) L1 is
• wherein m is an integer from 0 to 6,
• R2 and R3 are independently H, an unsubstituted alkyl, or a substituted alkyl;
• (iv) M′ is a parent drug moiety;
• and
• (v) each substituent is independently a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted polyaryl, a substituted or unsubstituted polyheteroaryl, a substituted or unsubstituted aralkyl, a carbonyl, an alkoxy, a halogen, a hydroxyl, a phenoxy, a thiol, an alkylthio, a phenylthio, an arylthio, a cyano, an isocyano, a nitro, a carboxyl, an amino, an amido, an oxo, a silyl, a sulfinyl, a sulfonyl, a sulfonic acid, a phosphonium, a phosphanyl, a phosphoryl, or a phosphonyl.