US 2026/0098017 A1 · NOVEL AROMATIC RING DERIVATIVE CONTAINING AMIDE SUBSTITUTION AND USE THEREOF

Abstract

The present invention belongs to the technical field of medicine, and in particular relates to a novel aromatic ring derivative containing an amide substitution or a pharmaceutically acceptable salt thereof. The diseases comprise, but are not limited to, inflammatory or autoimmune diseases such as psoriasis, psoriatic arthritis, dermatitis, lupus erythematosus, inflammatory bowel disease, hidradenitis suppurativa, rheumatoid arthritis, and uveitis. The structure of the compound of formula I is as described in the claims and the description. The aromatic ring derivative containing an amide substitution provided in the present invention is used as a novel TYK2 inhibitor, has a good TYK2 inhibitory effect, has a good therapeutic effect in an in vivo model of psoriasis and asthma animals, and has good druggability, high stability and good safety.

Claims21

Dependent claims

A novel aromatic ring derivative containing an amide substitution or a pharmaceutically acceptable salt thereof, characterized in that, the compound is expressed by formula I:

wherein, in the compound of formula I, X and P are selected independently from each other, and:
X is selected from CH, N;
P is selected from C1-C6 alkyl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted five-membered heteroaryl, substituted or unsubstituted six-membered heteroaryl, wherein the substituent is selected from one or more of:
C1-C6 alkyl, C3-C6 cycloalkyl, halogen, C1-C6 alkoxy, C1-C6 haloalkyl, and —CN;
when X is N, P is as defined above;
or
when X is CH, P is as defined above.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

19/142,338Filed 22 Dec 2023

Priority

CN 202211669072.624 Dec 2022

Published

9 Apr 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification23 codes

A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system
C07D 237/24
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
A61K 31/44
Having six-membered rings with one nitrogen as the only ring hetero atom: non condensed pyridines; Hydrogenated derivatives thereof
A61K 31/4439
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole

Novel aromatic ring derivative containing amide substitution and use thereof

Life of this patent

Novel aromatic ring derivative containing amide substitution and use thereof

Life of this patent

Abstract

Claims21