Tissue isolation devices capable of repeated inflation and deflation in vivo

A tissue isolation device capable of repeated inflation and deflation in vivo, comprising:

• an isolation balloon, wherein the isolation balloon is arranged between healthy tissues and target tissues for a radiotherapy course, and the isolation balloon is removed from a body of a target subject following the radiotherapy course;
• the isolation balloon is operable to assume an inflated state and a deflated state, the isolation balloon in the inflated state is used to isolate the healthy tissues and the target tissues, and the isolation balloon in the deflated state is used to maintain a physiological state of the healthy tissues and the target tissues;
• the isolation balloon includes a first contact surface and a second contact surface, in the inflated state, the first contact surface contacts the healthy tissues, and the second contact surface contacts the target tissues;
• and
• when the isolation balloon is in the inflated state, a minimum distance between the first contact surface and the second contact surface is greater than or equal to a distance required for a radiation dose to fall off to within a tolerance threshold of the healthy tissues, a maximum distance between the first contact surface and the second contact surface is less than or equal to a maximum tolerable distraction distance of the healthy tissues.