US 2026/0097224 A1 · METHODS FOR MODULATING NEUROPLASTICITY

Abstract

Disclosed is a method for providing targeted energy-based neurostimulation treatment of the brain of a patient in need of such treatment, which method involves administering to said patient prior to or simultaneously with administration of said targeted neurostimulation treatment sufficient amount of a dopamine receptor agonist in combination with one or more drugs that modulate or enhance neuroplasticity of the brain of the patient, and repeating said targeted neurostimulation treatment for a time period not exceeding one day. In a preferred embodiment the treatment is for depression, and the targeted neurostimulation treatment involves transcranial magnetic stimulation.

Claims19

Dependent claims

A treatment protocol for treating a condition of the central nervous system (CNS) in an individual in need of treatment, wherein the condition comprises a condition selected from the group consisting of an anxiety disorder;

a stress disorder;
a psychotic disorder;
a personality disorder;
an impulse-control disorder;
an addiction disorder;
an eating disorder;
a sleep disorder;
a sexual disorder;
a neurodevelopmental disorder;
a neurological disorder;
and a functional performance domain;
the treatment protocol comprising administering to the individual at least one neuroplasticity-potentiating pharmaceutical agent, and delivering a multi-session energy-based neuromodulation treatment to said individual over multiple sessions within a time period equal to or less than five half-life time periods of the at least one neuroplasticity-potentiating pharmaceutical agent, of the time of administration of the at least one neuroplasticity-potentiating pharmaceutical agent to said individual.

9 more elements

A method for enhancing and/or accelerating a therapeutic effect of a multi-session energy-based neuromodulation treatment of the central nervous system (CNS) in an individual to treat a condition selected from the group consisting of an anxiety disorder;

a stress disorder;
a psychotic disorder;
a personality disorder;
an impulse-control disorder;
an addiction disorder;
an eating disorder;
a sleep disorder;
a sexual disorder;
a neurodevelopmental disorder;
a neurological disorder;
and a functional performance domain;
the method comprising administering to the individual (1) at least one neuroplasticity-potentiating pharmaceutical agent selected from the group consisting of an N-methyl-D-aspartate (NMDA) receptor modulator;
a non-NMDA glutamatergic modulator;
a monoaminergic modulator;
a cholinergic modulator;
a gamma-aminobutyric acid (GABAergic) modulator;
an opioidergic modulator;
an endocannabinoid modulator;
a cellular signaling modulator;
an epigenetic modulator;
a transcriptional modulator;
a structural modulator;
a synaptic modulator;
a neurotrophic modulator;
a neuroimmune modulator;
and a glial modulator, and (2) a dopamine agent, and delivering said energy-based neuromodulation treatment of said individual in a series of sessions beginning within a time period less than a five half-life time period of said at least one neuroplasticity-potentiating pharmaceutical agent and said dopamine agent after administering the at least one of the neuroplasticity-potentiating pharmaceutical agent and the dopamine agent.

23 more elements

A method for enhancing and/or accelerating a therapeutic effect of an energy-based multi-session neuromodulation treatments of the central nervous system (CNS) in an individual to treat a condition selected from the group consisting of an anxiety disorder;

a stress disorder;
a psychotic disorder;
a personality disorder;
an impulse-control disorder;
an addiction disorder;
an eating disorder;
a sleep disorder;
a sexual disorder;
a neurodevelopmental disorder;
a neurological disorder;
and a functional performance domain;
the method comprising administering to the individual at least one two pharmaceutical agents including (1) at least neuroplasticity-potentiating pharmaceutical agent, selected from the group consisting of an N-methyl-D-aspartate (NMDA) receptor modulator;
a non-NMDA glutamatergic modulator;
a monoaminergic modulator;
a cholinergic modulator;
a gamma-aminobutyric acid (GABAergic) modulator;
an opioidergic modulator;
an endocannabinoid modulator;
a cellular signaling modulator;
an epigenetic modulator;
a transcriptional modulator;
a structural modulator;
a synaptic modulator;
a neurotrophic modulator;
a neuroimmune modulator;
and a glial modulator;
and (2) a dopaminergic agent, wherein said at least one neuroplasticity-potentiating agent and said dopaminergic agent are administered to said individual during or between said multi-session treatments of said individual.

24 more elements

A method for enhancing and/or accelerating a therapeutic effect of an energy-based neuromodulation multi-session treatments of the central nervous system (CNS) in an individual to treat a condition selected from the group consisting of an anxiety disorder;

a stress disorder;
a psychotic disorder;
a personality disorder;
an impulse-control disorder;
an addiction disorder;
an eating disorder;
a sleep disorder;
a sexual disorder;
a neurodevelopmental disorder;
a neurological disorder;
and a functional performance domain;
the method comprising delivering said energy-based neuromodulating treatment to said individual, and administering to the individual at least two pharmaceutical agents including (1) at least one neuroplasticity-potentiating pharmaceutical agent, selected from the group consisting of an N-methyl-D-aspartate (NMDA) receptor modulator;
a non-NMDA glutamatergic modulator;
a monoaminergic modulator;
a cholinergic modulator;
a gamma-aminobutyric acid (GABAergic) modulator;
an opioidergic modulator;
an endocannabinoid modulator;
a cellular signaling modulator;
an epigenetic modulator;
a transcriptional modulator;
a structural modulator;
a synaptic modulator;
a neurotrophic modulator;
a neuroimmune modulator;
and a glial modulator;
and (2) a dopaminergic agent, wherein said at least one neuroplasticity-potentiating agent and said at least one dopamine agent are administered to said individual following said multi-session treatment of said individual.

24 more elements

Dependencies are inferred from the claim text.

Methods for modulating neuroplasticity

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Methods for modulating neuroplasticity

Life of this patent

Abstract

Claims19