Systems and methods of safe model-based multivariable control of peritoneal perfusion

An automatically controlled peritoneal perfusion system, comprising:

• a reservoir configured to hold a perfusate;
• an inflow pump fluidly coupled to the reservoir and configured to deliver the perfusate to a peritoneal cavity of a subject;
• an outflow pump fluidly coupled to the peritoneal cavity and configured to withdraw the perfusate and return the perfusate to the reservoir;
• a plurality of sensors comprising at least one weight sensor, at least one flow-rate sensor, and at least one pressure sensor;
• at least one processor;
• and
• at least one memory storing instructions, which when executed by the processor, cause the system to:
• receive perfusion parameters including at least a target intra-abdominal volume and a target inflow rate;
• circulate the perfusate between the reservoir and the peritoneal cavity using the inflow pump and the outflow pump;
• measure a reservoir volume using the weight sensor;
• generate inflow data using the flow-rate sensor;
• access commanded outflow rate from the outflow pump;
• estimate a drainage efficiency of the outflow pump based at least on the reservoir volume, the inflow data, and the commanded outflow rate;
• and
• apply a perfusion safety control routine that evaluates the estimated drainage efficiency relative to the perfusion parameters and adjusts operation of the inflow pump and the outflow pump based on the evaluation.

A non-transitory computer-readable medium storing instructions that, when executed by at least one processor, cause a system for automated peritoneal perfusion to:

• receive perfusion parameters, the perfusion parameters including at least a predefined intra-abdominal volume and a predefined inflow rate;
• circulate a perfusate between a reservoir and a cavity of a subject using an inflow pump and an outflow pump;
• measure a reservoir volume using a weight sensor positioned beneath the reservoir;
• generate inflow data using a flow-rate sensor coupled to the inflow pump;
• access a commanded outflow rate from the outflow pump;
• estimate a drainage efficiency of the outflow pump based on at least the reservoir volume, the inflow rate, and the commanded outflow rate;
• identify a drainage efficiency model from experimental or operational data to represent efficiency dynamics;
• and
• apply a perfusion safety control routine that evaluates a safety barrier function based on the drainage efficiency model and adjusts circulation of perfusate between the inflow pump and the outflow pump based on the evaluated safety barrier function.