Method for treating neurodegenerative diseases

A method of treating a neurodegenerative disease, comprising the step of administering to a subject in need thereof an effective amount a nanocomplex having (a) an outer shell comprising one or more polymer-flavonoid conjugates, (b) optionally an inner shell comprising one or more flavonoid oligomer, and (c) anti-CD3 antibody or anti-CD33 antibody encapsulated within the shell or shells;

• wherein the flavonoid is EGCG, EC, EGC, or ECG, as shown in the structures below:
• the polymer is a hydrophilic polymer having a molecular weight of 1,000 to 100,000 daltons, and is selected from the group consisting of:
• poly(ethylene glycol) (PEG), hyaluronic acid, dextran, polyethylenimine, poloxamers, povidone, D-alpha-tocopheryl, and polyethylene glycol succinate;
• the flavonoid oligomer comprises 2-20 flavonoids of EGCG, EC, EGC, or ECG;
• the neurodegenerative disease is selected from the group consisting of:
• Alzheimer's disease, Parkinson's disease, Lewy body dementia and Huntington's disease.