Antibody-drug conjugate comprising drug and antibody specifically binding to grp94 or antigen-binding fragment thereof

An antibody-drug conjugate (ADC) comprising an antibody or an antigen-binding fragment thereof that specifically binds to GRP94, and a drug, wherein the antibody or antigen-binding fragment thereof comprises:

• (i) a heavy chain complementarity-determining region 1 (HCDR1) comprising the amino acid sequence of SEQ ID NO:
• 1, a heavy chain complementarity-determining region 2 (HCDR2) comprising the amino acid sequence of SEQ ID NO:
• 2, a heavy chain complementarity-determining region 3 (HCDR3) comprising the amino acid sequence of SEQ ID NO:
• 3, a light chain complementarity-determining region 1 (LCDR1) comprising the amino acid sequence of SEQ ID NO:
• 4, a light chain complementarity-determining region 2 (LCDR2) comprising the amino acid sequence of SEQ ID NO:
• 5, and a light chain complementarity-determining region 3 (LCDR3) comprising the amino acid sequence of SEQ ID NO:
• 6;
• or
• (ii) a HCDR1 comprising the amino acid sequence of SEQ ID NO:
• 9, a HCDR2 comprising the amino acid sequence of SEQ ID NO:
• 10, a HCDR3 comprising the amino acid sequence of SEQ ID NO:
• 11, a LCDR1 comprising the amino acid sequence of SEQ ID NO:
• 12, a LCDR2 comprising the amino acid sequence of SEQ ID NO:
• 13, and a LCDR3 comprising the amino acid sequence of SEQ ID NO:
• 14.