Back to results
US 2026/0097105 A1Published application
Systems, formulations and methods for generating universal peptide/mhc complexes with engineered disulfide connecting the heavy and light chains
OwnerNikolaos SGOURAKISinventor
Life of this patent
Estimating the term…
Abstract
The present invention relates to engineering synthetic major histocompatibility complex (MHC) molecules for generating universal peptide/MHC complexes with engineered disulfide linkage(s) using structure-guided modeling and design and method for making and using the same.
Claims17
A complex comprising
- (a) a protein encoding any one of (i) a dsMHC sequence of any one of Tables 1-6 and/or (ii) a sequence in FIG. 2 or FIG. 9A with a G120 mutation and/or a H31 mutation and
- (b) a peptide or a ligand capable of eliciting an immune response.
Dependencies are inferred from the claim text.