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US 2026/0097100 A1Published application
Cancer treatment by induction of tumor and stem cell differentiation
OwnerKeith Roger Latham, Regina L. Garlandinventors
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OwnerKeith Roger Latham, Regina L. Garlandinventors
Estimating the term…
A method and composition for treating cancer through induction of tumor cell differentiation is disclosed. Cancer cells are converted into terminally differentiated, non-proliferating cell types using specific differentiation-inducing agents, including thyroid hormone analogs such as T2 and RT3. The approach avoids the cytotoxic effects and side effects associated with conventional chemotherapy while potentially providing curative treatment. Pharmaceutical compositions include topical formulations for skin cancer treatment and various delivery systems for systemic administration. In vitro screening methods for identifying differentiation-inducing agents are also provided.
A method for treating cancer comprising administering to a patient in need thereof a therapeutically effective amount of a differentiation-inducing agent capable of converting cancer cells into terminally differentiated, non-proliferating cells.
A pharmaceutical composition comprising a differentiation-inducing agent and a pharmaceutically acceptable carrier, wherein the differentiation-inducing agent is capable of inducing cancer cell differentiation.
A method for screening differentiation-inducing agents comprising:
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