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AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsJe-Yong CHOI, Xiangguo CHE, Xian JIN
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The present invention relates to a pharmaceutical composition containing Cbfβ (Core-binding factor subunit beta) expressing vascular smooth muscle cells or a culture fluid thereof as an active ingredient for the prevention or treatment of age-related diseases. It has been found that inhibition of Cbfβ expression in vascular smooth muscle cells promotes vascular calcification and osteoclast differentiation and that the culture fluid of Cbfβ-expressing vascular smooth muscle cells inhibits osteoclast differentiation. Thus, the composition can be advantageously utilized as a pharmaceutical composition for the prevention, treatment, alleviation, or diagnosis of age-related diseases.
A method for preventing or treating a geriatric disease, comprising administering a pharmaceutical composition comprising a pharmaceutically effective amount of a core-binding factor subunit beta (Cbfβ)-expressing vascular smooth muscle cell or a culture fluid thereof as an active ingredient to a subject in need of preventing or treating the geriatric disease.
A method for preventing or ameliorating a geriatric disease, comprising administering a health functional composition comprising a therapeutically effective amount of a core-binding factor subunit beta (Cbfβ)-expressing vascular smooth muscle cell or a culture fluid thereof as an active ingredient to a subject in need of preventing or treating the geriatric disease.
A method for preventing or treating a geriatric disease, comprising administering a pharmaceutically effective amount of a pharmaceutical composition comprising an agent which induces expression or activity of a core-binding factor subunit beta (Cbfβ) protein or a gene encoding the same as an active ingredient to a subject in need of preventing or treating the geriatric disease.
8-18. (canceled)
Dependencies are inferred from the claim text.