Cannabinoid analogs and methods of use for treatment and prevention of cancer

A compound of formula I or formula II:

• wherein
• X is H, halogen, CF3, or OR2;
• R2 is CF3, or C1-6 alkyl;
• Y is H, or two adjacent Y are taken together to form a 3-membered heterocylcoalkyl ring, or two adjacent Y are taken together to form a 3-membered cycloalkyl ring optionally substituted with two R3;
• Each R3 is independently H or F;
• Z is OR4;
• R4 is H, C1-9 substituted or unsubstituted alkyl, C1-9 substituted or unsubstituted alkenyl, C1-9 substituted or unsubstituted alkynyl, OC(O)(CH2)nC(O)O-gemcitabine, or OC(O)(CH═CH)nC(O)O-gemcitabine, wherein n is an integer from 1-20;
• R is halogen, C1-9 substituted or unsubstituted alkyl, C1-9 substituted or unsubstituted alkenyl, C1-9 substituted or unsubstituted alkynyl, benzyl, aryl, —S—C1-6 alkyl-CH═CH2, substituted or unsubstituted pyrrole, substituted or unsubstituted thiophene, substituted or unsubstituted furan, or OR5;
• and
• R5 is H, C1-9 substituted or unsubstituted alkyl, C1-9 substituted or unsubstituted alkenyl, or C1-9 substituted or unsubstituted alkynyl.