Methods for treating a fatty liver disease

A method of improving liver fibrosis comprising:

• determining a weight of adult human subject in need thereof;
• and
• based on determination of the weight of the adult human subject in need thereof, administering to the adult human subject in need thereof a solid oral dosage form comprising:
• (i) resmetirom or a pharmaceutically acceptable salt thereof at a dosage of 80 mg per day, if the adult human subject in need thereof is determined to weigh 100 kg or more and the adult human subject in need thereof is using a moderate CYP2C8 inhibitor;
• or
• (ii) resmetirom or the pharmaceutically acceptable salt thereof at a dosage of 60 mg per day, if the adult human subject in need thereof is determined to weigh less than 100 kg and the adult human subject in need thereof is using a moderate CYP2C8 inhibitor;
• and
• wherein the adult human subject in need thereof has liver fibrosis associated with nonalcoholic steatohepatitis (NASH).