Method of treating cancer using a combination of quinoline derivative and antibody

A method for treating cancer in an entity, comprising administering to the entity a therapeutically effective amount of an anti-PD-1 antibody or an antigen-binding fragment thereof and a therapeutically effective amount of a tyrosine kinase inhibitor,

• wherein the anti-PD-1 antibody comprises:
• HCDR1 comprising a sequence set forth in SEQ ID NO:
• 25, HCDR2 comprising a sequence set forth in SEQ ID NO:
• 26, HCDR3 comprising a sequence set forth in SEQ ID NO:
• 27, LCDR1 comprising a sequence set forth in SEQ ID NO:
• 28, LCDR2 comprising a sequence set forth in SEQ ID NO:
• 29, and LCDR3 comprising a sequence set forth in SEQ ID NO:
• 30,
• wherein the tyrosine kinase inhibitor is a compound of formula I or a pharmaceutically acceptable salt thereof,
• wherein the cancer is liver tumor or lung cancer.