Extended release formulations comprising substituted indazole propionic acid derivative compounds and uses thereof

A composition comprising:

• a) a compound of Formula (I):
• a pharmaceutically acceptable salt, a tautomer, or a pharmaceutically acceptable salt of the tautomer thereof, wherein:
• A1 is CR8, or N;
• A2 is CH2, CHD, CD2, S, O, or NH;
• A3 is CH, CD, or N;
• R1 is H, D, C1-8alkyl, C3-6cycloalkyl, or 4-6 membered heterocycloalkyl, each of which is optionally substituted;
• R2, R3, R5, and R6 are each independently H, D, OH, or halogen;
• R4 is monocyclic aryl, bicyclic aryl, monocyclic heteroaryl, or bicyclic heteroaryl, each of which is optionally substituted with R9, R10, R11, R12, or R13,
• wherein R9, R10, R11, R12, and R13 are each independently H, D, halogen, CN, oxo, C1-8alkyl, C3-6cycloalkyl, examC0-6alkylene-ORx, C1-6haloalkylene-ORx, C0-6alkylene(C0-6haloalkyl)NRRy, C1-6alkylene(C1-6haloalkyl)NRRy, 4-6 membered heterocycloalkyl, C(O)ORx, C0-6alkylene-C(O)NRxRy, OC1-3alkylene-heterocycloalkyl, OC1-3alkylene-C(O)NRxRy, O(C1-6alkyl)SO2NRxNRy, NRxRy, NHSO2Rx, SRx, S—C1-6alkylene-C(O)NRxRy, S(O)RxRy, SO2Rx, SO2NRxRy, S(O)(NRx)Ry, S(O)(NRx)Ry, or SO2Rx;
• wherein each Rx and Ry is independently H, D, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C3-6cycloalkyl, C1-6alkylene-amide, OC0-2alkylene-heterocycloalkyl, 4-6 membered heterocycloalkyl, C(O)C1-6alkyl, imino, or C1-6alkylsulfonyl;
• or Rx and Ry together with the atoms to which Rx and Ry are bound can form an optionally substituted ring;
• R7 is C1-3alkyl, C3-6cycloalkyl, cyano, or halogen;
• Rb1, Rb2, and Rb3 are each independently H or D;
• R3 is H, D, or halogen;
• and
• n is 0, 1, or 2;
• b) a matrix component;
• and
• c) a release modifier,
• wherein the composition is an extended-release composition.