Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
AssigneeEpicentRx, Inc.
InventorsBryan T. ORONSKY, Jan SCICINSKI, Scott CAROEN
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Abstract
The invention provides compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl) ethanone (ABDNAZ), including formulations containing autologous whole blood and ABDNAZ that can be rapidly administered to a patient by intravenous infusion without any significant pain at the site of infusion.
Claims112
A method for intravenous administration of an ABDNAZ formulation to a patient suffering from cancer in order to treat the cancer, comprising intravenously administering to the patient in need thereof a therapeutically effective amount of an ABDNAZ formulation comprising whole blood, ABDNAZ, and an anticoagulant, in order to treat the cancer.
A method for rapid intravenous administration of an ABDNAZ formulation to a patient while minimizing injection site pain experienced by the patient, comprising intravenously administering to the patient at a rate of at least 10 mL/hour an ABDNAZ formulation comprising whole blood, ABDNAZ, and an anticoagulant, wherein any pain experienced by the patient at the site of intravenous administration of the ABDNAZ formulation due to intravenous administration of the ABDNAZ formulation is no greater than Grade 2.
An intravenous formulation containing ABDNAZ for intravenous administration to a patient, comprising:
- a. whole blood in an amount of at least 60% v/v of the formulation;
- b. a polyethylene glycol at a concentration of from about 0.4 μL/mL to about 30 μL/mL in the formulation;
- c. N,N-dimethylacetamide at a concentration of from about 0.2 μL/mL to about 15 μL/mL in the formulation;
- d. ABDNAZ at a concentration of at least 10 μg/mL in the formulation;
- e. water;
- and
- f. an anticoagulant.
The intravenous formulation of any one of claims 78-81, wherein the polyethylene glycol is a polyethylene glycol having a number average molecular weight in the range of about 200 g/mol to about 600 g/mol.
Dependencies are inferred from the claim text.