Back to results
US 2026/0097012 A1Published application
Compositions and methods for treating graft-related arrhythmia
AssigneeBlueRock Therapeutics LP
InventorsIbrahim Domian, Rocco Romagnuolo
Life of this patent
Estimating the term…
Abstract
Provided herein are methods of treating or preventing an arrhythmia in a cardiac graft patient, wherein the method comprises administering combinations of anti-arrhythmic agents (e.g., amiodarone, metoprolol, ivabradine, and/or mexiletine) to the subject in need thereof.
Claims87
A method comprising administering two or more of:
- amiodarone,
- metoprolol,
- ivabradine, and
- mexiletine,
- optionally each of which independently comprises an analog or derivative thereof, or a pharmaceutically acceptable salt, isotopically labeled compound, tautomer, stereoisomer, solvate, tautomer, hydrate, polymorph, co-crystal, or prodrug thereof,
- to a subject in need thereof, wherein the subject is in need of or has received a cardiac graft.
3 more elements
A pharmaceutical composition comprising two or more of:
- amiodarone,
- metoprolol,
- ivabradine,
- mexiletine,
- lidocaine,
- verapamil, and
- procainamide,
- optionally each of which independently comprises an analog or derivative thereof, or a pharmaceutically acceptable salt, isotopically labeled compound, tautomer, stereoisomer, solvate, tautomer, hydrate, polymorph, co-crystal, or prodrug thereof;
- and
- optionally a pharmaceutically acceptable excipient.
7 more elements
A kit comprising:
- (1) two or more of:
- amiodarone,
- metoprolol,
- ivabradine, and/or
- mexiletine,
- optionally each of which independently comprises an analog or derivative thereof, or a pharmaceutically acceptable salt, isotopically labeled compound, tautomer, stereoisomer, solvate, tautomer, hydrate, polymorph, co-crystal, or prodrug thereof;
- and
- (2) instructions for administering (1) to treat or prevent arrhythmia in a subject in need thereof.
5 more elements
Dependencies are inferred from the claim text.