Implantable Device for Administering a Therapeutic Agent
AssigneeCelanese EVA Performance Polymers LLC
InventorsHarsh Patel, Jeffrey Haley
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Abstract
An implantable device for the delivery of a therapeutic agent is provided. The implantable device includes a core having a core polymer matrix within which is dispersed one or more therapeutic agents. The core polymer matrix includes a hydrophobic polymer comprising a first poly ortho ester (POE) polymer. The first POE polymer has a Tg of between about −20° C. and 40° C. as determined in accordance with ASTM E1640-18. Methods for forming the implantable device are also provided.
Claims20
An implantable device for delivery of a therapeutic agent, comprising:
- a core comprising a core polymer matrix within which is dispersed one or more therapeutic agents, wherein the core polymer matrix comprises a hydrophobic polymer comprising a first poly ortho ester (POE) polymer, wherein the first POE polymer has a Tg of between about −20° C. and 40° C. as determined in accordance with ASTM E1640-18.
A method of manufacturing an implantable device, comprising:
- melt-blending a core polymer matrix containing a first POE polymer and one or more therapeutic agents in an extruder barrel at a first temperature, the first temperature ranging from about 40° C. to about 70° C., the first POE polymer having a Tg of from about −20° C. to about 40° C. as determined in accordance with ASTM E1640-18;
- mixing the core polymer matrix and therapeutic agent in the extruder barrel at a second temperature to form a mixture of core polymer matrix and one or more therapeutic agents, the second temperature ranging from about 40° C. to about 70° C.;
- extruding the mixture of core polymer matrix and one or more therapeutic agents from the extruder barrel forming a core of the implantable device;
- cooling the core;
- and
- cutting the core to form the implantable device.
Dependencies are inferred from the claim text.