Multi chamber flexible bag and methods of using same

A flexible pharmaceutical bag comprising:

• a first chamber configured to hold a lyophilized pharmaceutical product;
• a second chamber configured to hold a reconstituting solution for reconstituting the lyophilized pharmaceutical product in the first chamber;
• a seal disposed between the first chamber and the second chamber that separates and seals the first chamber from the second chamber;
• and
• a first port attached to the first chamber, the first port configured to introduce a pharmaceutical product into the first chamber and allow passage of water vapor from the pharmaceutical product during lyophilization of the pharmaceutical product,
• wherein the lyophilized pharmaceutical product is 200 mg or 400 mg of thiotepa.

A flexible pharmaceutical bag comprising:

• a front film;
• a back film;
• an outer seal joining the front film to the back film around a perimeter of the pharmaceutical bag;
• and
• a breakable seal joining the front film and the back film interior of the outer seal, the breakable seal defining a first chamber and a second chamber separated from the first chamber,
• wherein the first chamber is configured to hold a lyophilized pharmaceutical product,
• wherein the second chamber is configured to hold a reconstituting solution for reconstituting the lyophilized pharmaceutical product in the first chamber,
• wherein the breakable seal breaks before the outer seal when a predetermined amount of pressure is applied to the flexible pharmaceutical bag, and
• wherein the lyophilized pharmaceutical product is 200 mg or 400 mg of thiotepa.

A flexible pharmaceutical bag comprising:

• a first chamber configured to hold a lyophilized pharmaceutical product;
• a second chamber configured to hold a reconstituting solution for reconstituting the lyophilized pharmaceutical product in the first chamber;
• a seal disposed between the first chamber and the second chamber that separates and seals the first chamber from the second chamber;
• and
• a first port attached to the first chamber, the first port configured to introduce a pharmaceutical product into the first chamber and allow passage of water vapor from the pharmaceutical product during lyophilization of the pharmaceutical product,
• wherein the reconstituting solution is 0.9% saline solution, and
• wherein the lyophilized pharmaceutical product is 200 mg of thiotepa.

A flexible pharmaceutical bag comprising:

• a first chamber configured to hold a lyophilized pharmaceutical product;
• a second chamber configured to hold a reconstituting solution for reconstituting the lyophilized pharmaceutical product in the first chamber;
• a seal disposed between the first chamber and the second chamber that separates and seals the first chamber from the second chamber;
• and
• a first port attached to the first chamber, the first port configured to introduce a pharmaceutical product into the first chamber and allow passage of water vapor from the pharmaceutical product during lyophilization of the pharmaceutical product,
• wherein the reconstituting solution is 0.9% saline solution, and
• wherein the lyophilized pharmaceutical product is 400 mg of thiotepa.