Systems, devices, and methods for controlling actuation of tissue resection devices

An apparatus, comprising:

• a first actuator coupled to a helical coil of a tissue excision device, the helical coil including a first electrode on a surface thereof, the first actuator configured to rotate a shaft coupled to the helical coil to cause the helical coil to rotate distally through tissue;
• a second actuator coupled to a tubular assembly including a second electrode on a distal end thereof, the second actuator configured to apply a first force to the tubular assembly to move the tubular assembly distally to clamp a portion of tissue between the first electrode and the second electrode, the first electrode and the second electrode configured to be activated with energy to seal vessels in the portion of tissue when the portion of tissue is clamped between the first electrode and the second electrode;
• and
• a third actuator coupled to the tubular assembly, the third actuator configured to apply a second force to the tubular assembly after the portion of tissue is sealed to cause a cutting device disposed within the tubular assembly to advance through the portion of tissue to cut the portion of tissue.

An apparatus, comprising

• one or more actuators configured to cause one or more tubular members to advance through lung tissue, seal a portion of the lung tissue, and cut the portion of the lung tissue to form a tissue column in an inner volume defined by the one or more tubular members;
• a retraction mechanism configured to cause the one or more tubular members to withdraw proximally to expose a snare near a distal end of the one or more tubular members;
• and
• a snare actuator moveable to a first position to cause the snare to move a distal portion of the tissue column toward a first electrode and a second electrode such that the first electrode and the second electrode can seal the distal portion of the tissue column, the snare actuator further moveable from the first position to a second position to cause the snare to sever the tissue column from surrounding tissue.

An apparatus, comprising:

• a housing defining an inner volume;
• an actuator disposed on the housing and coupled to a tubular member, the actuator configured to cause the tubular member to rotate distally through tissue of a lung;
• a locking mechanism at least partially disposed in the housing, the locking mechanism in a locked configuration configured to prevent movement of the actuator, the locking mechanism configured to transition from an unlocked configuration to the locked configuration when a distal end of the tubular member is at a predetermined depth relative to a surface of the lung;
• and
• a shaft configured to extend through the inner volume of the housing such that a portion of the shaft is slidably disposed through a portion of the locking mechanism, the shaft coupled to a tissue anchor configured to anchor to a target tissue site in the lung, the shaft including a groove configured to engage with the portion of the locking mechanism when the distal end of the tubular member is at the predetermined depth, to transition the locking mechanism to the locked configuration.