Use of discoidin domain receptor 2 in diagnosis of neurodegenerative diseases, and related computer readable medium

A method for treating a neurodegenerative disease in a subject, the method comprising:

• (a) bringing a sample from the subject into contact with an agent capable of binding to discoidin domain receptor 2 (DDR2);
• (b) detecting and reading a signal of the sample after the contact to determine whether the agent forms a complex with DDR2 in the sample;
• (c) determining whether the signal exceeds a predetermined threshold, and when the signal exceeds the predetermined threshold, determining that the subject has the neurodegenerative disease, and wherein the threshold is a median level from subjects not having the disease;
• and (d) administering a neuroprotective or neurorestorative therapy to the subject determined to have the neurodegenerative disease.

A computer-readable storage medium having stored thereon computer instructions for reading and execution by a computer, the computer instructions being executed to perform a method for diagnosing whether a subject has a neurodegenerative disease, the method comprising:

• (a) bringing a sample from the subject into contact with an agent capable of binding to discoidin domain receptor 2 (DDR2);
• (b) detecting and reading a signal of the sample after the contact to determine whether the agent forms a complex with DDR2 in the sample;
• and
• (c) determining whether the signal exceeds a predetermined threshold, and when the signal exceeds the predetermined threshold, determining that the subject has the neurodegenerative disease, and wherein the threshold is a median level from subjects not having the disease.

A method for treating a neurodegenerative disease in a subject, the method comprising:

• (a) isolating an exosome from the subject;
• (b) bringing the isolated exosome into contact with an agent capable of binding to discoidin domain receptor 2 (DDR2);
• (c) detecting and reading a signal of the exosome after the contact to determine whether the agent forms a complex with DDR2 in the exosome;
• (d) determining whether the signal exceeds a predetermined threshold, and when the signal exceeds the predetermined threshold, determining that the subject has the neurodegenerative disease, and wherein the threshold is a median level from subjects not having the disease;
• and (e) administering a neuroprotective or neurorestorative therapy to the subject determined to have the neurodegenerative disease.