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US 2026/0092282 A1Published application
Dna-rna heteroduplex targeting androgen receptor
OwnerHan-Oh PARK, June Young PARK +3inventors
InventorsHan-Oh PARK, June Young PARK, Sung Il YUn, Sang Kyu LEE, Woorim CHOI
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Abstract
The present disclosure provides a DNA-RNA heteroduplex targeting and inhibiting expression of androgen receptor and its composition. The DNA-RNA heteroduplex and the composition can be used to inhibit a symptom associated with expression of androgen receptor. In particular, the method of using the DNA-RNA heteroduplex and the composition for hair improvement, increase of hair growth, or decrease of hair loss are provided.
Claims61
A DNA-RNA heteroduplex, comprising:
- a. a DNA strand having the sequence of SEQ ID NO:
- 1 or 3,
- b. an RNA strand having the sequence of SEQ ID NO:
- 2 or 4, or a modified RNA strand comprising the sequence of SEQ ID NO:
- 2 or 4 with one or more modifications,
- c. stearyldisulfidehexyl (C6—S—S—C18) covalently attached to 5′-end of the DNA strand;
- and
- d. hexaethylene glycol (HEG) or polyethylene glycol (PEG) covalently attached to 3′-end of the DNA strand,
- wherein the DNA strand and the RNA strand or the modified RNA strand form a DNA-RNA hybrid.
6 more elements
Dependencies are inferred from the claim text.