Fusion protein complexes for use in epigenetic regulation and use thereof
AssigneeUniversity-Industry Cooperation Group of Kyung Hee University
InventorsSeung Ja Oh, Na Ly Tran
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Abstract
The disclosure relates to a fusion protein including a transcription enhancer and a dCas9 protein, a complex for epigenetic regulation including the fusion protein and one or more guide RNAs (gRNAs), etc. The fusion protein or complex according to an aspect may induce apoptosis of colorectal cancer cells or compensate for rhodopsin deficiency by activating the gene EGFL8, opsin mw, etc., and may be utilized as a pharmaceutical composition or the like for preventing or treating cancer or ocular diseases.
Claims9
A fusion protein comprising a transcription enhancer and an inactivated Cas9 (dCas9) protein,
- wherein the transcription enhancer is SETD7 or a variant thereof.
A complex for epigenetic regulation, comprising:
- a fusion protein comprising a transcription enhancer and an inactivated Cas9 (dCas9) protein;
- and one or more guide RNAs (gRNAs),
- wherein the transcription enhancer is SETD7 or a variant thereof.
Dependencies are inferred from the claim text.