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US 2026/0092098 A1Published application
Human a interferon receptor binding-related site mutant and use thereof
AssigneeFudan University
InventorsZhenghong YUAN, Jieliang CHEN, Yaming LI
Life of this patent
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Abstract
Provided is a human a interferon receptor binding-related site mutant IFN-α2-EIFK. The mutant has stronger anti-hepatitis B virus activity than IFN-α2, and has no cytotoxic effect at an antiviral concentration. An anti-hepatitis B virus drug can be prepared therefrom.
Claims11
A human interferon alpha receptor 2 (IFN-α2) mutant, comprising the amino acid sequence of SEQ ID NO:
- 1 with one or more substitutions selected from D82E, T86I, Y89F, and R120K.
Dependencies are inferred from the claim text.