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US 2026/0092076 A1Published application
Novel compounds
AssigneeHoffmann-La Roche Inc.
InventorsLewis Scott AITKEN, Lea Aurelie BOUCHE, Wolfgang GUBA, Georg Stefan JAESCHKE, Stefanie Katharina MESCH, Christian SCHNIDER, Jonathan Martin SHANNON, Sandra STEINER
Life of this patent
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Abstract
The invention relates to novel compounds having the general formula I wherein R1, R2, R3, A and W are as described herein, composition including the compounds and methods of using the compounds.
Claims30
A compound of formula I:
- wherein,
- R1 is H, alkyl, hydroxyalkyl or alkoxyalkyl;
- R2 is halo, haloalkyl or cyano;
- R3 is H;
- or R2 and R3, and the atoms to which they are bonded, form a 4-6 membered heterocycle ring comprising a single O heteroatom optionally substituted with one or two substituents independently selected from halo and alkyl,
- or R2 and R3, and the atoms to which they are bonded, form a 3-6 membered cycloalkyl ring optionally substituted with one or two substituents independently selected from halo and alkyl;
- A is CH or N;
- W is:
- p is 1 or 2;
- q is 1 or 2;
- m is 0 or 1;
- Y1 is C═O, CH, CH2, C—Rx, N, or NH;
- Y2 is C═O, CH, C—Ry, O, N, NH, or N—CH3;
- Y3 is C═O, CH, CH2, CRy, N, NH, or NRz;
- Y4 is C═O, CH, CRy, N, NH or N—CH3;
- wherein Rx is H and each Ry is independently selected from —OH, alkyl, alkoxy, cyano and halo, or Rx+Ry, through the atoms to which they are attached, form a heterocycle ring;
- Rz is H, alkyl or hydroxyalkyl;
- and pharmaceutically acceptable salts thereof.
15 more elements
5-6. (canceled)
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13-14. (canceled)
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24-27. (canceled)
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33-34. (canceled)
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Dependencies are inferred from the claim text.