Inhibitors of canine janus kinase and uses thereof

A compound having a structure according to Formula I:

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• R1 is H or optionally substituted C1-C3 alkyl;
• n=0 or 1;
• R2 is H or CH3;
• R3 is C1-C4 alkyl, phenyl,
• wherein:
• m is 0 or 1;
• X is H, F, Cl, OCH3, or CH3,
• R4 is H or CH3,
• R5 is H, C1-C4 alkyl, C3-C5 cycloalkyl, CH2CH2OCH3, or 2-pyrimidinyl;
• or
• R4 and R5, together with the included N atom, form a 4-, 5- or 6-membered ring,
• wherein said 6-membered ring optionally includes one additional heteroatom selected from N and O;
• or
• R2 and R3, together with the included N atom, form a 6-membered ring, optionally substituted with C1-C4 alkyl, C7 to C12 aralkyl, or —C(O)—NR6R7,
• wherein:
• R6 is H or C1-C4 alkyl;
• R7 is H, C1-C4 alkyl, phenyl;
• or
• R6 and R7, together with the included N atom, form a 6-membered ring which may optionally be substituted with C1-C4alkyl, and wherein said 6-membered ring optionally includes one additional N atom.