Method for preparing 2-hydroxyethyl aminocaproate compound and use thereof

A method for preparing a compound of formula I or a pharmaceutically acceptable salt thereof,

• comprising a step of reacting a compound of formula A with a compound of formula B to form a compound of formula I,
• wherein L1 and L2 are each independently selected from the group consisting of —C(O)O—, —OC(O)—, —C(O)— and —OC(O)O—;
• H1 and H2 are each independently selected from the group consisting of C1-12 heteroalkylene, C1-12 alkylene and C2-12 alkenylene;
• H3 is selected from the group consisting of C1-24 alkylene, C2-24 alkenylene, C3-8 cycloalkylene and C3-8 cycloalkenylene;
• H4 is selected from the group consisting of C2-11 heteroalkylene, C2-11 alkylene and C3-11 alkenylene;
• R1 and R2 are each independently selected from the group consisting of C1-24 alkyl and C2-24 alkenyl;
• R3 is selected from the group consisting of —CN, —C(O)OR4, —OC(O)R4, —OR5 and —NR5C(O)R4, R4 is selected from the group consisting of C1-6 alkyl and C2-6 alkenyl, and R5 is selected from the group consisting of hydrogen, C1-6 alkyl and C2-6 alkenyl.