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US 2026/0091389 A1Published application
Microfluidic on-chip filters
Assignee10x Genomics, Inc.
InventorsJorge BERNATE, Rajiv BHARADWAJ, Donald A. MASQUELIER, Tobias Daniel WHEELER
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Abstract
A microfluidic system for manipulating particles in a fluid is provided. The system includes a microfluidic chip having at least one channel and at least one filter feature, wherein the filter feature includes a field of physical obstacles configured and arranged to remove physical contaminants associated with the particles. The filter features are particularly suited to remove contaminants associated with gel beads manipulated by microfluidic handling.
Claims21
1-85. (canceled)
A method for filtering particles in a fluid, comprising:
- (a) providing a microfluidic device comprising:
- (i) a reservoir configured to hold the fluid comprising the particles,
- (ii) a channel in fluid communication with the reservoir, and
- (iii) at least one filter feature disposed within the channel, the at least one filter feature comprising a plurality of physical obstacles arranged in the channel and at least one passage between the plurality of physical obstacles and through the filter feature, the passage having a cross-section of at least 30 μm;
- wherein the channel comprises a first end and a second end, the first end being directly connected to the reservoir and disposed between the reservoir and the second end;
- and
- wherein the at least one filter feature is (1) at least partially located in a tapered portion of the channel at the first end that decreases in cross-section along a direction from the first end to the second end, or (2) located in a portion of the channel comprising a contraction followed by an expansion, the contraction and expansion being between an upstream end and a downstream end of the plurality of physical obstacles of the at least one filter feature;
- and
- (b) transporting the fluid from the reservoir through the at least one filter feature, wherein the particles are trapped by the at least one filter feature.
6 more elements
Dependencies are inferred from the claim text.