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US 2026/0091114 A1Published application
Chimeric antigen receptors binding nectin-4
AssigneeFred Hutchinson Cancer Center
InventorsJohn K. Lee, Li-Ting Wu
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Abstract
Chimeric antigen receptors (CAR) with a binding domain that binds Nectin-4 are disclosed. The Nectin-4 binding domain can be derived from the murine antibody M22-321b41.1. The CAR disclosed herein can be expressed by an immune cell to be used in the treatment of Nectin-4-expressing cancers, such as bladder, breast, ovarian, esophageal, lung, colorectal, or pancreatic cancers.
Claims93
A chimeric antigen receptor (CAR) comprising, when expressed by a cell,
- an extracellular component comprising a Nectin-4 binding domain;
- an intracellular component comprising an effector domain;
- and
- a transmembrane domain linking the extracellular component to the intracellular component.
1 more element
Dependencies are inferred from the claim text.