Cyclic peptide derivative composition for treating or preventing eye disease

A method for treating or preventing an ophthalmic disease, comprising administering to a subject an effective amount of a compound represented by the following Formula (1):

• or a pharmaceutically acceptable salt, solvate or prodrug thereof:
• wherein
• R1, R2, R5, R6, R7, R8, R9 and R10 are each independently
• a hydrogen atom, or
• an optionally substituted hydrocarbon group, or
• R7 and R8, together with the carbon atom and nitrogen atom to which they are attached, form an optionally substituted heterocycloalkyl group,
• R3 and R4 are each independently
• a hydrogen atom, an optionally substituted hydrocarbon group, a carboxyl group,
• an optionally substituted alkoxycarbonyl group, or
• an optionally substituted alkoxycarbonyloxy group,
• R11, R12, R13, and R14 are each independently
• a hydrogen atom, an optionally substituted hydrocarbon group, a hydroxy group,
• an optionally substituted alkoxy group, or
• an optionally substituted alkoxycarbonyloxy group,
• X is CH2 or CO, and
• A is O, NH or S, wherein the NH is optionally substituted.