Compositions and methods for treating degenerative, age-related and trauma-induced disorders
AssigneeS.I.S. Shulov Innovative Science Ltd.
InventorNaftali PRIMOR
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Abstract
Pharmaceutical compositions containing specific tetrapeptides for use in treating, preventing, minimizing, diminishing or reversing degenerative, age-related, or trauma-induced diseases or disorders in a subject in need thereof. The disease may be a disease associated with ROS-related oxidative stress. The tetrapeptides may have an amino acid sequence of pGlu-Asn-Trp-Lys(Octanoyl)-OH as set forth in SEQ ID NO: 1 or pGlu-Asn-Trp-Thr-OH as set forth in SEQ ID NO: 2, preferably as a sodium salt thereof.
Claims20
A method of treating a degenerative, age-related, or trauma-induced disease or disorder in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising as an active ingredient a peptide of Formula I:
- pGlu-X1-X2-X3-OH, wherein X1 is selected from the group consisting of Asn, Gln, His, Ser, Thr, Tyr, and Cys;
- X2 is selected from the group consisting of Trp, Phe, Tyr, Ala, Ile, Leu, Met, Val, and Gly;
- and X3 is selected from the group consisting of Lys, Lys attached through its amino side chain to a C4-C30 alkyl group, Arg, His, Asn, Gln, Ser, Thr, and Tyr;
- and a pharmaceutically acceptable excipient.
A method of treating a disease associated with ROS-related oxidative stress in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising as an active ingredient a peptide of Formula I:
- pGlu-X1-X2-X3-OH, wherein X1 is selected from the group consisting of Asn, Gln, His, Ser, Thr, Tyr, and Cys;
- X2 is selected from the group consisting of Trp, Phe, Tyr, Ala, Ile, Leu, Met, Val, and Gly;
- and X3 is selected from the group consisting of Lys, Lys attached through its amino side chain to a C4-C30 alkyl group, Arg, His, Asn, Gln, Ser, Thr, and Tyr;
- and a pharmaceutically acceptable excipient.
An isolated sodium salt of a peptide having a sequence as set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.