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US 2026/0091049 A1Published application
Halide-free ammonium silanes
AssigneeTopikos Scientific, Inc.
InventorsGary Allred, Lanny Liebeskind, William R. Cast, Carl Hilliard
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Abstract
Provided herein are ammonium silanes, compositions, their formulations, including powdered and solid formulations, and methods of use to treat infections in humans and animals. The ammonium silanes and compositions described herein can also be used as a preservative, disinfectant, or in another anti-microbial use.
Claims21
A topical formulation comprising:
- i) an excipient of Formula A:
- or a pharmaceutically acceptable salt thereof;
- and
- ii) a compound of Formula B, selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- each R is independently selected from the group consisting of OH and alkoxy;
- G is hydrogen or alkyl;
- R2 is C1-C6 alkyl;
- R3 is C1-C6 alkyl;
- X1 is selected from the group consisting of a bond,
- X2 is selected from the group consisting of
- Z is selected from the group consisting of —SO3H, —SO3−, and —SO3M;
- A− is absent or a non-halogen anion;
- M is a metal cation;
- and
- n is selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, and 18.
14 more elements
Dependencies are inferred from the claim text.